We are an international and interdisciplinary team (biologists, biochemists, bioinformaticians, physicists, ...) and communication is key. Meet the team.
How do our genes interact to create the bewildering diversity of cell types, tissues, and organs? Can we identify perturbations of these interactions that cause or drive the onset of diseases? And how can we predict and target early disease trajectory for therapy before symptoms appear?
To answer these questions, we pursue, for 20 years, a strongly interdisciplinary approach by integrating biochemistry, molecular biology, and data sciences. We are mainly working with patient samples (numerous collaboration with the Charité hospital Berlin) and patient-derived organoids. Our research questions often require us to develop or apply new methods to quantify how cells read and interpret the book of life (the genome) in health and in disease. We use data sciences (including machine learning) and our brains to interpret these data and to make predictions about mechanisms which we then test directly in the lab. A long-standing special interest of the lab is to understand the function of the non-coding genome/RNA (miRNAs, circRNAs, long-non-coding RNAs, ...).
Diseases currently studied in the lab: Cancer (Triple negative breast cancer, non-small cell lung cancer, neuroblastoma), Neurodegenerative diseases and impact of infections on brain development. How do our genes interact to create the bewildering diversity of cell types, tissues, and organs? Can we identify perturbations of these interactions that cause or drive the onset of diseases? And how can we predict and target early disease trajectory for therapy before symptoms appear? Read more about our research.
We are always looking for skilled people!
Whether your weapon of choice is pipette or keyboard (or both): if you have the impression that this lab is doing interesting research that you would like to contribute to, do not hesitate to contact us.
If you are able to (and enjoy) discussing your work with people from other disciplines this lab may be just right!
Hannoversche Str. 28, 10115 Berlin
Phone +49 30 9406 2999 (Alex Tschernycheff, Secretary)
Fax +49 30 9406 3868
We are located within a few minutes walk from several public transport stations, such as Oranienburger Tor, Oranienburger Straße, and only one stop away from the public transport hub Friedrichstraße. From Oranienburger Straße, the train S2 connects us directly to the MDC Campus in Berlin-Buch.
S-Bahn: S2 (to MDC Berlin-Buch) and S1, S25, S26
U-Bahn: U6
Tram: M1, M5, 12
Bus: 142
